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Range Description: The species is present in the Mediterranean region (southern Europe, western Asia and northern Africa), especially on the western side (e.g. Category: cosmetic ingredient for skin conditioning. Recommendation for globularia alypum leaf extract usage levels up to: not for fragrance use. Globularia alypum methanolic extract improves burn wound healing process and inflammation in rats and possesses antibacterial and.

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Acute toxicity study in mice The determination of the acute toxicity of G. Support Center Support Center. Globularia is a genus of about 22 species of flowering plants in the family Plantaginaceaenative to central and southern Europe, Macaronesia, northwest Africa and southwest Asia. Leaves of Gobulaira alypum L.

Spermatogenesis study after administration by the oral route of Globularia alypum L. Moreover and in certain cases, it has been used the following histo-chemical colorations: This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

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J Sci Med Sport. A group served as the control group received alypym water. Approximately 50 g of leaf material was ground in a blender with 50 ml of distilled water for 3 min.

The effect of G. The determination of the acute toxicity of G. You can help Wikipedia by expanding it. Globulariaceae is a widely growing shrub in the Mediterranean area known for its uses in popular medicine for several properties: National Center for Biotechnology InformationU. Antioxidative effect of compounds isolated from Globularia alypum L. It has also to be pointed out that the observed vascular congestion was nearly constant in the all the groups of animals treated with G.

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Quantification of globularin Globularin, a principal iridoid glucosid present in G. During the treatment period, the animals, maintained by groups of 10 in Macrolon cages The first one is concerned by the recorded hyperprotidemia and hyperglycemia. By using this site, you agree to the Terms of Use and Privacy Policy. During the treatment period, a control group of 10 male rats weighing This lesion was selectively more pronounced in male than in female rats.

Anemia induces accumulation of erythopoietin in the kidney and the liver. Lungs Histological examination of this organ showed the existence of a pronounced thinning of pulmonary arteriolar wall meaning the presence of histological grades I to II pulmonary hypertension PHT [ Figure 4a ].

These differences, globu,aria pronounced in female than in male rats, showed a dose-dependent decrease in growth weight. Laboratory 35, Rue de Palestine, Tunis, Tunisia for biochemical and hematological analysis.

However, it has been noted on day D 5 the appearance of liquid stools in the four treated groups of animals.

Muscular strength, body composition and health responses to the use of testosterone enanthate: Badreddine Fehri, Boite Postale B.

Please review our privacy policy. Under the old Cronquist system of plant classification, they were treated in their own family, Globulariaceaebut genetic evidence has shown that the genus belongs in the family Plantaginaceae. In this respect, G. At day D 16all the animals were killed and the testis of experimental animals were removed for histological examination.

Retrieved from ” https: Moreover, it has been observed in treated males that the intra-alveolar spaces were invaded by eosinophil granulocytes associated to a septa capillary congestion that would correspond to a beginning of a respiratory distress syndrome ARDS [ Figure 4a ]. Myorelaxant and spasmalytic effects of Globularia alypum L. Daily clinical examination did show any significant change in gross general behavior spontaneous motor activity, reactivity, gait, respiration. Table 3 Results of histological examinations.


Toxicity by reiterated administrations Clinical examination No mortality was observed in all experimental animal groups. The concentration of globularin in the aqueous extract of G. The drug also induced at this level a vascular congestion, an important lymphoid hyperplasia, and a dystrophic dilatation of pulmonary alveoli with nearly the same importance in all male and female treated animals. Feb, [Retrieved on Nov 24].

Globularia alypum L., – Turbith – Overview

Kidneys In general, the histological structure of the glomerulus was respected in all the observed groups and it has neither been observed membrane globukaria nor hyperplasia of mesangial cells or deposits of immunoglobulins.

The drug, dissolved in water, has been administrated by oral and intra-peritoneal routes to ten mice groups according to doses chosen in geometrical progression of 1: It has notably not been observed any loss of substance nor inflammatory infiltrate or lymphoid hyperplasia [ Figure 4c ]. J Pharmacol Exp Ther. After drying in air, the leaves were used to prepare aqueous extract using water. It is suggested that the G. Investigations carried out during the treatment period During the treatment period, the animals were clinically followed up, daily weighed, determination of food and water consumption, measure of blood pressure and cardiac pulse rate at root tail level with a B.